Experimental cardiovascular simulation, quantitative device characterization, and computational modeling of heart–LVAD interactions.
The SDSU cardiovascular simulator reproduces heart-failure physiology and circulatory loading conditions while integrating ventricular assist devices. Programmable ventricular contraction, bioprosthetic valves, and adjustable vascular resistance and compliance allow controlled studies of the native heart and mechanical support.
Dynamic H–Q loops quantify the interaction of native cardiac contraction and LVAD support. Experimental studies extended the external-work balance to partial bypass, accounting for forward aortic flow and aortic compliance.
May-Newman, Artificial Organs (2022) ↗
A simple mathematical model informed by mock-loop measurements explored the timing of the HeartMate 3 artificial pulse relative to native contraction. Optimized timing approximately doubled flow pulsatility without materially changing mean flow.
May-Newman, ASAIO Journal (2022) ↗
The NSF–FDA project is developing a lumped-parameter computational counterpart of the SDSU cardiovascular simulator. Measurements from the physical system inform model development and validation, while computational predictions are evaluated against experimental behavior.
NSF/FDA SiR: FDA Scholar in Residence Program 2426859 — Development of a Regulatory Science Tool for Virtual Design of Novel Ventricular Pump Strategies.